A fine - tuned interaction between the trimeric autotransporter 1 Haemophilus surface fibrils and vitronectin leads to serum resistance 2 and adherence to respiratory epithelial cells
نویسندگان
چکیده
Medical Microbiology, Department of Laboratory Medicine Malmö, Lund University, Jan 7 Waldenströms gata 59, SE-205 02 Malmö, Sweden, Department of Infection Biology, Leibniz 8 Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, D-07745 9 Germany, Section of Clinical and Experimental Infectious Medicine, Department of Clinical 10 Sciences, Lund University, SE-221 84 Lund, Sweden, and Division of Medical Protein Chemistry, 11 The Wallenberg Laboratory, Department of Laboratory Medicine Malmö, Lund University, 12 Skåne University Hospital, SE-205 02 Malmö, Sweden. 13
منابع مشابه
A fine-tuned interaction between trimeric autotransporter haemophilus surface fibrils and vitronectin leads to serum resistance and adherence to respiratory epithelial cells.
Haemophilus influenzae type b (Hib) escapes the host immune system by recruitment of the complement regulator vitronectin, which inhibits the formation of the membrane attack complex (MAC) by inhibiting C5b-C7 complex formation and C9 polymerization. We reported previously that Hib acquires vitronectin at the surface by using Haemophilus surface fibrils (Hsf). Here we studied in detail the inte...
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